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Mauricio Gomes Constantino

Full Professor, FFCLRP-USP, since 2006
Member of the University staff since 1975
(Regional Editor of Molecules)

B. Sc. ("Licenciatura") (1970)
M. Sc. (1974)
Ph. D. (1977)
Postdoctoral fellow (USA, 1979-1980)
"Livre-Docente" (1982)
Postdoctoral fellow (Germany and England, 1985)

 

Research: Synthesis of Natural Products

Our main interest is the synthesis of biologically active natural products. Abscisic acid (a vegetal hormone) and Artemisinin (a strong anti-malaria agent) are illustrative examples of substances already synthesized in our laboratory.

Fig1MauEMaior.gif (5001 bytes)

We are presently developing methods for the synthesis of goyazensolide, of products extracted from Otoba parvifolia, of microbiotol, etc. See under Current Research for more details.

We do also some investigations on novel organic reactions, analytical methods and development of software and equipment for research and educational purposes. See under Software some of the programs we have developed as part of our research work.

Selected Publications

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Synthesis
bulletM. G. Constantino, P. M. Donate and N. Petragnani, "An Efficient Synthesis of (±)-Abscisic Acid", J. Org. Chem. 51, 253 (1986).
bulletM. G. Constantino, P. M. Donate and N. Petragnani, "Hydration of Diacetylene Compounds. Synthesis of a Marine Natural Product: (±)-1-(2,6,6-Trimethyl-4-hydroxycyclohexenyl)--1,3-butanedione", J. Org. Chem. 51, 387-390 (1986).
bulletM. G. Constantino, P. Losco and E. E. Castellano, "A Novel Synthesis of (±)-Abscisic Acid", J. Org. Chem. 1989, 54, 681-683.
bulletM. G. Constantino, M. Beltrame Jr., G. V. J. da Silva and J. Zukerman-Schpector, "A Novel Asymmetric Synthesis of (+)-Artemisinin", Synth. Commun. 26, 321-329 (1996).
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Organic Reactions
bulletM. G. Constantino, I. Carvalho, G. V. J. da Silva and F. C. Archanjo, "Hydration of Acetylenic Esters: Synthesis of b -Keto-Esters", Molecules 1996, 1, 72-78. Reprint.
bulletM. G. Constantino, L. G. O. Matias, G. V. J. da Silva, V. C. G. Heleno and M. T. P. Gambardella, "Stereoselective Synthesis of b -Hydroxy- and b -Ethoxy-d -lactones: Model Structures for Compounds Isolated from Otoba parvifolia", Synth. Commun. 27, 4285-4295 (1997).
bulletM. G. Constantino, L. G. O. Matias, G. V. J. da Silva, E. Barbieri and M. T. P. Gambardella, "Stereoselective Sodium Borohydride Reductions of Cyclopentanones: Influence of Ceric Chloride on the Stereochemistry of Reaction", Química Nova 21, 719-721 (1998).
bulletP. M. Donate, M. G. Constantino, R. da Silva and S. Pedersoli, "Synthesis of Substituted g-Butyrolactones: b-Hydroxymethyl-, b-Methylene and Cyclopropane Derivatives", Synth. Commun.29, 2923-2936 (1999).
bulletM. G. Constantino, P. M. Donate, D. Frederico, T. V. Carvalho, L. E. Cardoso and J. Zukerman-Schpector, "Ring Contraction Through Epoxide Rearrangement: A Formal Synthesis of Capsorubin", Synth. Commun., in press.
bulletG. V. J. da Silva, V. C. G. Heleno and M. G. Constantino, "Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide", Molecules 2000, 5, 908-915. Reprint.
bulletM. G. Constantino, A. Beatriz, G. V. J. da Silva and J. Zukerman-Schpector, "Synthetic Studies on the Diels-Alder Adduct from 3,4-Dimethoxyfuran and Benzoquinone", Synth. Commun., in press.
bulletM. G. Constantino, V. Lacerda Jr. and V. Aragão, "Niobium Pentachloride Catalysed Ring Opening of Epoxides", Molecules 2001, 6, 770-776. Reprint.
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NMR and Theoretical Studies
bulletM. G. Constantino and G. V. J. da Silva, "Stereochemistry in Substituted Cyclopentanes: An Approach to the Analysis by Proton NMR", Tetrahedron 54, 11363-11364 (1998).
bulletM. G. Constantino, V. Lacerda Jr., G. V. J. da Silva, L. Tasic and R. Rittner, "Principal Component Analysis of Long Range "W" Coupling Constants of Some Cyclic Compounds", J. Mol. Struc. 2001, 597/1-3, 129-136.
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Education, Equipment, etc.
bulletM. G. Constantino, "Utilização de Micro-Computadores em Aulas de Ressonância Magnética Nuclear de Próton", Química Nova 11, 299 (1988).
bulletM. G. Constantino and G. V. J. Silva, "Um Desumidificador de Ar para Aparelhos de RMN", Química Nova 12, 174 (1989).
bulletI. Carvalho, M. G. Constantino and G. V. J. Silva, "Simples e Eficiente Método para Dosar LDA", Química Nova 12, 177 (1989).
bulletM. G. Constantino and E. R. Oliveira, "Um Seguro Controle de Aquecimento para Laboratório", Química Nova 14, 120 (1991).
bulletM. G. Constantino, G. V. J. da Silva and M. M. M. Pelisson, "Moléculas em Três Dimensões: Um Estereoscópio Para Computador", Química Nova 21, 337-340 (1998).
bulletM. G. Constantino and A. X. de Souza, "Modelos Para o Carbono sp3: Quatro Pirâmides no Tetraedro", Química Nova 21, 662-665 (1998).
bulletM. G. Constantino and G. V. J. da Silva, "A Transformada de Fourier em Basic", Química Nova 23, 413-417 (2000).

This page was last updated on 08/20/10